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Moderate folic acid supplementation and MTHFD1-synthetase deficiency in mice, a model for the R653Q variant, result in embryonic defects and abnormal placental development
birth defects developmental defects embryo folic acid high folate methylenetetrahydrofolate reductase MTHFD1 placenta
2018/12/19
Background: Moderately high folic acid intake in pregnant women has led to concerns about deleterious effects on the mother and fetus. Common polymorphisms in folate genes, such as methylenetetrahydro...
Fortification with low amounts of folic acid makes a significant difference in folate status in young women: implications for the prevention of neural tube defects
Neural tube defects folic acid fortification
2016/6/1
Mandatory fortification of grain products with folic
acid was introduced recently in the United States, a policy expected
to result in a mean additional intake of 100 mg/d. One way of predicting
th...
Tessier Number 30 Clefts With Congenital Heart Defects
Facial Median Cleft Congenital Heart Defects
2015/10/22
Introduction: Midline cleft of mandible, classified as Tessier 30 clefts is extremely rare, with less than 100 reported cases in the latest studies. Variations in severity and associated malformations...
Formulas for the force dipole interaction of surface line defects in homoepitaxy
Formulas for the force surface line defects homoepitaxy
2015/10/16
Using asymptotics, we derive explicit, simplified formulas for integrals representing the force dipole interaction energy per unit length between line defects (steps) of the same sign that form pertur...
Configuration of VLSI Arrays in the Presence of Defects
Circuit area fault tolerance percolation theory probabilistic analysis queuing processes systolic arrays
2015/8/14
The penalties for configuring VLSI arrays for yield enhancement are assessed. Each dement of the fabricated array is assumed to be defective with independent probability p. A fixed fractmn R of the el...
Configuration of VLSI Arrays in the Presence of Defects
Circuit area fault tolerance percolation theory probabilistic analysis queuing processes systolic arrays wafer-scale integration wire length
2015/8/12
The penalties for configuring VLSI arrays for yield enhancement are assessed. Each dement of the fabricated array is assumed to be defective with independent probability p. A fixed fractmn R of the el...
A computer memory with defects is modeled as a discrete memoryless channel with states that are statistically determined. The storage capacity is found when complete defect information is given to the...
Evaluation of the activity of intraarticular hyaluronic acid in the repair of experimentally induced osteochondral defects of the stifle joint in dogs
osteochondral defect hyaluronic acid dog
2015/4/2
The present study examined the results of using hyaluronic acid with autogenetic cancellous grafts in the treatment of experimentally induced osteochondral defects in the stifle joints of dogs. In thi...
Localized breathing modes in granular crystals with defects
One dimensional chain tight elastic beads Hertz interaction breathing pattern
2014/12/24
We study localized modes in uniform one-dimensional chains of tightly packed and uniaxially compressed elastic beads in the presence of one or two light-mass impurities. For chains composed of beads o...
Risk Factors of Neural Tube Defects in Northern Iran
Neural Tube Defects Ethnicity Body Mass Index Nutritional Sciences
2015/10/13
Background:: Neural tube defects (NTDs) including spina bifida and anencephaly are the second most common birth defects with 2.8 per 1000 births in northern Iran.
Dissecting the cellular and molecular mechanisms mediating neurofibromatosis type 1 related bone defects
Mouse model Osteoclasts Transforming growth factor-beta1
2015/5/21
Skeletal manifestations including short stature, osteoporosis, kyphoscoliosis, and tibial dysplasia cumulatively affect approximately 70% of patients with neurofibromatosis type 1 (NF1). Tibial pseuda...
One-Stage Repair and Reconstruction of Craniomaxillofacial Bone Defects
Craniomaxillofacial Bone Defects Repair and Reconstruction
2013/1/30
Objective: Severe craniomaxillofacial injuries and craniomaxillofacial tumors can lead to craniomaxillofacial bone defects and deformities. Seriously affect the patients’ appearance and quality of lif...
Aged rat heart: Modulation of age-related respiratory defects decreases ischemic-reflow injury
Mitochondria Cytochrome Oxidase Complex III Myocardial Infarction Aging
2013/1/29
Myocardial injury increases in the elderly heart during ischemia and reperfusion. Mitochondria, the key targets and sources of injury during ischemia and reperfusion, sustain ischemic damage to the el...
Geometrical defects in two-dimensional melting of many-particle Yukawa systems
Geometrical defects two-dimensional melting many-particle Yukawa systems Plasma Physics
2012/5/17
We perform Langevin dynamics simulations and use polygon construction method to investigate two-dimensional (2D) melting and freezing transitions in many-particle Yukawa systems. 2D melting transition...
Excitation of plasmons in two-dimensional electron gas with defects by microwaves: Wake-field method
plasmons two-dimensional electron gas microwaves Wake-field method
2011/8/17
Abstract: We develop an analytical method to find plasmons generated by microwaves in a two-dimensional electron gas with defects. The excitations are expressed in terms of the wake field of a charged...