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Introduction: Intraoperative nerve monitoring is used in otolaryngology to assist in identification of nerves at risk. It is hoped that this will lead to lower rates of nerve injury. The objective of ...
Salivary gland tumours (SGT) are rare, comprising about 5% of head and neck tumours with a higher incidence reported in the western compared with the African centres. There are few studies on SGTs tha...
Immunofluorescence microscopy is widely used to analyze the subcellular locations of proteins, but current approaches relyon visual interpretation of the resulting patterns. To facilitate more rapid, ...
Automated Interpretation of Protein Subcellular Location Patterns: Implications for Early Cancer Detection and Assessment.
Fluorescence microscope images capture information from an entire field of view, which often comprises several cells scattered on the slide. We have previously trained classifiers to accurately pre...
Fluorescence microscopy is widely used to analyze the distribution of proteins within cells. As currently practiced, the assignment of a protein to a particular organelle is done by visual inspecti...
The ongoing biotechnology revolution promises a complete understanding of the mechanisms by whichcells and tissues carry out their functions. Central to that goal is the determination of the function ...
The central goal of proteomics is to clarify the mechanism by which each protein in a given cell type carries out itsfunction. Automated protein subcellular location determination by fluorescence micr...
The ongoing biotechnology revolution promises a complete understanding of the mechanisms by which cells and tissues carry out their functions. Central to that goal is the determination of the functi...
A Neural Network Classifier Capable of Recognizing the Patterns of all Major Subcellular Structures in Fluorescence Microscope Images of HeLa Cells.
There is extensive interest in automating the collection, organization and analysis of biological data. Data in the form of images present special challenges for such efforts. Since fluorescence mi...
Determination of the functions of all expressed proteins represents one of the major upcoming challenges in computational molecular biology. Since subcellular location plays a crucial role in prote...
The widespread proliferation of automated fluorescence-microscope systems has made the acquisition of digital images commonplace in cell-biology research. This has created a need for computer app...
Methods for numerical description and subsequent classification of cellular protein localization patterns are described. Images representing the localization patterns of 4 proteins and DNA were ob...

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