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The influence of ovariectomy,simvastatin and sodium alendronate on alveolar bone in rats
Alendronate Models animal Osteoporosis Ovariectomy Simvastatin
2009/10/19
Bisphosphonates are currently used in the treatment of many diseases involving increased bone resorption such as osteoporosis. Statins have been widely used for the treatment of hypercholesterolemia a...
Controlled Release of Simvastatin Acid Using Cyclodextrin Inclusion System
Simvastatin acid Cyclodextrin derivative Controlled drug release
2009/9/14
Simvastatin acid (SVA) has been reported to stimulate bone formation by increasing expression of BMP-2 in osteoblasts. Due to their multi-functional characteristics and bioadaptability, cyclodextrins ...
Induction of TGF-β and BMP-2 by Simvastatin in Human Periodontal Ligament Cells
simvastatin human periodontal ligament (HPDL) cells transforming growth factor-β1 (TGF-β1) bone morphogenetic protein-2 (BMP-2)
2009/5/21
Statins, which are highly effective cholesterol-lowering drugs, induce bone morphogenetic protein (BMP)-2 expression. However, the other growth factors except for BMP-2 and the effects of statins on p...