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The SLC2A14 gene, encoding the novel glucose/dehydroascorbate transporter GLUT14, is associated with inflammatory bowel disease
genetic association SLC2A14 vitamin C antioxidants inflammatory bowel disease
2018/11/21
Background: Variations in intestinal antioxidant membrane transporters are implicated in the initiation and progression of inflammatory bowel disease (IBD). Facilitated glucose transporter member 14 (...
Inflammatory potential of the diet and colorectal tumor risk in persons with Lynch syndrome
adapted dietary inflammatory index colorectal adenoma
2018/11/20
Background: Persons with Lynch syndrome (LS) have high lifetime risk of developing colorectal tumors (CRTs) because of a germline mutation in one of their mismatch repair (MMR) genes. An important pro...
Substituting whole grains for refined grains in a 6-wk randomized trial has a modest effect on gut microbiota and immune and inflammatory markers of healthy adults
gut microbiota healthy adults immune inflammation whole grains
2018/11/13
Background: Observational studies suggest an inverse association between whole-grain (WG) consumption and inflammation. However, evidence from interventional studies is limited, and few studies have i...
Possible new approach to fighting chronic inflammatory diseases
chronic inflammatory diseases arthritic disease
2014/7/15
Researchers from The University of Queensland’s Institute for Molecular Bioscience have discovered a potential new approach to treating chronic inflammatory diseases such as arthritis.
Differences of Inflammatory Mechanisms in Asthma and COPD
bronchomotor tone inflammatory cells nitric oxide oxidative stress tachykinins
2010/11/16
Bronchial asthma and chronic obstructive pulmonary disease (COPD) are increasing common diseases. The major pathogenesis of both illnesses is chronic inflammation. However, the inflammatory pattern is...
Intussusception due to Inflammatory Fibroid Polyp Located at Ileum: Report of Two Cases
Inflammatory fibroid polyp intussusception small bowel
2009/6/17
Inflammatory fibroid polyps are uncommon gastrointestinal tract lesions. The stomach and ileum are the most commonly affected sites. Clinical symptoms depend on the location and size of the lesion. Ob...
Prostaglandin as a Target Molecule for Pharmacotherapy of Allergic Inflammatory Diseases
allergy anti-allergic drug PGD2 PGI2 prostaglandin
2010/11/17
The purpose of this review is to summarize the role of prostaglandins (PGs) in allergic inflammation and to know the value of PGs, as a target molecule for an anti-allergic drug.
PGD2 is the major PG...
Anti-inflammatory and bronchoprotective roles of endogenous prostaglandin E2
airway inflammation arachidonic acid aspirin-induced asthma asthma cyclo-oxygenase prostaglandin E2
2010/11/29
Prostaglandin E2 (PGE2) is produced by resident cells in the airway, such as airway epithelial cells, airway smooth muscle cells and alveolar macrophages, and is always present in the airway. Various ...
Interleukin-10 inhibits the production of inflammatory cytokines by antigen-stimulated mononuclear cells from asthmatic patients
bronchial asthma granulocytemacrophage colony stimulating factor interferon-γ interleukin-1β interleukin-2 interleukin-5 interleukin-10
2010/11/25
Bronchial asthma, characterized by chronic airway inflammation, involves many inflammatory cytokines. Interleukin (IL)-10 is a potent inhibitor of cytokine synthesis. Thus, the effects of IL-10 were e...
Evaluation of surrogate inflammatory markers for optimizing inhaled corticosteroid therapy in a real-life clinical setting
airway inflammation asthma bronchial hyperreactivity inhaled corticosteroids sputum eosinophils
2010/11/24
Background: To determine the effects of 1 months treatment with optimized high-dose inhaled corticosteroid on surrogate markers of airways inflammation, as well as lung function, in a clinical setting...
Anti-TNF Biological Agents in Rheumatoid Arthritis and Other Inflammatory Diseases
Monoclonal antibody RA Receptor antagonist TNF
2010/11/19
It is now evident that biological agents targeting on the tumor necrosis factor (TNF) have not only induce a substantial clinical response, but also inhibit the structural damage in patients with Rheu...
A Study of the Usefulness of Anti-inflammatory Treatment for Mild Intermittent Asthma (Step 1): Budesonide vs. Montelukast
airway hyperresponsiveness airway inflammation anti-inflammatory treatment early intervention exhaled nitric oxide induced sputum mild intermittent asthma
2010/11/19
Anti-inflammatory treatment is necessary even for mild intermittent asthma (step 1). We believe that early intervention with anti-inflammatory drugs is important for the prevention of airway remodelin...