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House Dust Mite Extract Induces Interleukin-9 Expression in Human Eosinophils
allergens eosinophils house dust mites interleukin-9 proteinase activated receptor 2
2010/11/17
Accumulated eosinophils in the airways in asthma may directly react with HDM and produce IL-9 to further promote Th2-type immune responses. Protease-activated receptor 2, a ligand for serine proteases...
Eotaxin-induced expression of membrane type 1 matrix metalloproteinase mRNA in human eosinophils
basement membrane degradation eosinophil eotaxin matrix metalloproteinase-2 matrix metalloproteinase-9 membrane-type matrix metalloproteinase
2010/11/25
Eosinophil penetration across the basement membrane (BM) is thought to be dependent on the degradation of membrane components. In this process, matrix metalloproteinases (MMP) appear to be primarily r...
Inhibitory effect of olopatadine hydrochloride (KW-4679), a novel antiallergic drug, on peptide leukotriene release from human eosinophils
antiallergic drug human eosinophils leukotriene olopatadine
2010/11/25
Olopatadine hydrochloride (olopatadine; KW-4679), (Z)-11-[(3-dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid monohydrochloride, is an antiallergic drug with selective and potent...
Prostaglandin D2 and interleukin-5 reduce CRTH2 surface expression on human eosinophils
CRTH2 eosinophils interferon-γ interleukin-4 interleukin-5 prostaglandin D2
2010/11/22
Background: Recently, a second prostaglandin D2 (PGD2) receptor, chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2), was identified. Because PGD2 was reported to have chemotac...