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THE MECHANISMS REGULATING THE TRANSCRIPTION FACTOR ATF5 AND ITS FUNCTION IN THE INTEGRATED STRESS RESPONSE
ATF5 stress uORF
2015/5/25
Phosphorylation of eukaryotic initiation factor 2 (eIF2) is an important mechanism regulating global and gene-specific translation during different environmental stresses. Repressed global translation...
Transcriptional regulation of ATF4 is critical for controlling the Integrated Stress Response during eIF2 phosphorylation
Transcriptional regulation ATF4
2015/5/25
In response to different environmental stresses, phosphorylation of eIF2 (eIF2P) represses global translation coincident with preferential translation of ATF4. ATF4 is a transcriptional activa...
The integrated stress response directs cell fate decisions in response to perturbations in protein homeostasis
diabetes cancer
2015/5/25
Disruptions of the endoplasmic reticulum (ER) cause perturbations in protein folding and result in a cellular condition known as ER stress. ER stress and the accumulation of unfolded protein activate ...