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Impact of polyunsaturated and saturated fat overfeeding on the DNA-methylation pattern in human adipose tissue: a randomized controlled trial
DNA methylation epigenetics EWAS Illumina 450k methylation array LIPOGAIN cohort obesity overfeeding polyunsaturated fat prediction saturated fat
2018/11/13
Background: Dietary fat composition can affect ectopic lipid accumulation and, thereby, insulin resistance. Diets that are high in saturated fatty acids (SFAs) or polyunsaturated fatty acids (PUFAs) h...
Interaction of an S100A9 gene variant with saturated fat and carbohydrates to modulate insulin resistance in 3 populations of different ancestries
gene-diet interaction insulin resistance SFA:carbohydrate ratio S100A9 gene type 2 diabetes
2018/12/13
Background: S100 calcium-binding protein A9 (S100A9) has previously been identified as a type 2 diabetes (T2D) gene. However, this finding requires independent validation and more in-depth analyses in...