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Next-generation DNA sequencing identifies novel gene variants and pathways involved in specific language impairment
ERC1 GRIN2A SRPX2
2017/8/25
A significant proportion of children have unexplained problems acquiring proficient linguistic skills despite adequate intelligence and opportunity. Developmental language disorders are highly heritab...
Vitamin D and incident dementia and cognitive impairment
Olsson incident dementia 25-hydroxyvitamin D 25(OH)D concentrations
2018/11/16
A study in Sweden by Olsson et al. (1) did not find an association of incident dementia or cognitive impairment with 25-hydroxyvitamin D [25(OH)D] concentrations measured at the time of enrollment for...
Vitamin D is not associated with incident dementia or cognitive impairment: an 18-y follow-up study in community-living old men
Alzheimer disease cognitive impairment cohort dementia Mendelian randomization vascular dementia vitamin D 25-hydroxyvitamin D
2018/11/13
Background: Vitamin D has been implicated as being important for maintaining cognitive function in old age. Results from longitudinal studies examining the association of vitamin D with incident demen...
Pacing Ability in Elite Runners with Intellectual Impairment
RUNNING ATHLETICS TRACK AND FIELD INTELLIGENCE
2018/4/24
Purpose To understand how athletes invest their energy over a race, differences in pacing ability between athletes with and without intellectual impairment (II) were explored using a novel field test....
Limitations of the review and meta-analysis of fish and PUFA intake and mild-to-severe cognitive impairment risks: a dose-response meta-analysis of 21 cohort studies
Limitation meta-analysis of fish 21 cohort studies
2018/12/13
The recent meta-analysis by Zhang et al. (1) on fish and PUFA intake and the risk of mild-to-severe cognitive impairment raises several methodologic issues that have important implications for the int...
Impairment of lysophospholipid metabolism in obesity: altered plasma profile and desensitization to the modulatory properties of n–3 polyunsaturated fatty acids in a randomized controlled trial
lysophospholipid metabolism lysophosphatidylcholine lysophosphatidylethanolamine obesity insulin resistance inflammation fatty
2018/12/13
Background: Plasma lysophospholipids have emerged as signaling molecules with important effects on inflammation, insulin resistance, and fatty liver disease, each of which is linked closely to obesity...
Impairment of lysophospholipid metabolism in obesity: altered plasma profile and desensitization to the modulatory properties of n–3 polyunsaturated fatty acids in a randomized controlled trial
DHA EPA nflammation men and women randomized controlled trial risk factors
2018/12/3
Background: To date, most studies on the anti-inflammatory effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in humans have used a mixture of the 2 fatty acids in various forms and...
Characterisation of CASPR2 deficiency disorder-a syndrome involving autism,epilepsy and language impairment
CNTNAP2 Epilepsy Intellectual disability Language regression Autism
2016/5/3
Background: Heterozygous mutations in CNTNAP2 have been identified in patients with a range of complex phenotypes including intellectual disability, autism and schizophrenia. However heterozygous CNTN...
Vitamin B-12 concentration, memory performance, and hippocampal structure in patients with mild cognitive impairment
episodic memory hippocampus MCI mean diffusivity vitamin B-12
2018/11/28
Background: Low-normal concentrations of vitamin B-12 (VitB12) may be associated with worse cognition. However, previous evidence has been mixed, and the underlying mechanisms remain unclear.
Intakes of fish and polyunsaturated fatty acids and mild-to-severe cognitive impairment risks: a dose-response meta-analysis of 21 cohort studies–
Alzheimer disease cognitive impairment dementia fish polyunsaturated fatty acids
2018/11/27
Background: The intake of fish and polyunsaturated fatty acids (PUFAs) may benefit cognitive function. However, optimal intake recommendations for protection are unknown.
A de novo FOXP1 variant in a patient with autism, intellectual disability and severe speech and language impairment
autism intellectual disability
2015/12/18
FOXP1 (forkhead box protein P1; OMIM 605515) belongs to the FOX
gene family of transcription factor proteins, defined by the presence of
a characteristic DNA-binding domain known as the forkhe...
Resumptive pronouns as a last resort when movement is impaired: Relative clauses in hearing impairment
pronouns Hearing impairment
2015/9/6
This study tested 14 school-age orally-trained children with hearing impairment who
have a deficit in A-bar movement, manifested in an impaired comprehension of object
relatives and topicalization...
MEASUREMENT OF PSYCHOLOGICAL IMPAIRMENT IN MATTERS OF CIVIL LITIGATION
PSYCHOLOGICAL IMPAIRMENT CIVIL LITIGATION
2015/7/23
American Medical Association published the 4th Edition of the "Guide
to the Evaluation of Permanent Impairment". Chapter 14 , "Mental and Behaviour
Disorders".
No right to speak?The relationship between object naming and semantic impairment:Neuropsychological evidence and a computational model
No right to speak object naming semantic impairment Neuropsychological evidence computational model
2015/6/19
No right to speak?The relationship between object naming and semantic impairment:Neuropsychological evidence and a computational model.
Can a perceptual processing deficit explain the impairment of inflectional morphology in developmental dysphasia?A computational investigation
perceptual processing deficit inflectional morphology developmental dysphasia computational investigation
2015/6/19
Developmental dysphasia (also referred to as specific language impairment) is a developmental language disorder in which children display delayed or abnormal language development but have normal non-v...