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北京大学深研院化生学院李志成课题组完成多个ent-Kuarene家族天然产物的全合成及其生物活性研究（图）
北京大学 深研院化生学院 李志成 ent-Kuarene家族天然产物 生物活性研究 细胞
2018/4/11
癌症是全球范围内导致死亡的第二大病因，化疗是目前治疗癌症的常用手段。天然产物在化疗药物的开发中极具价值，已经应用于临床的药品有紫杉醇、长春新碱、多柔比星等。ent-Kuarene家族天然产物分离自唇形科香茶菜属植物，该家族中7,20-epoxy-ent-kauranoids具有抗炎、抗肿瘤等生物学活性，是寻找化疗药物先导化合物的有效来源。目前，仅有两例7,20-epoxy-ent-kauranoi...
Stevioside and Rebaudioside A–Predominant Ent-Kaurene Diterpene Glycosides of Therapeutic Potential:a Review
Stevia rebaudiana secondary metabolites therapeutic applications sweetener
2016/12/9
Stevia rebaudiana (Bertoni) is a Paraguayan perennial herb of the family Asteraceae. The leaves contain a great amount of secondary metabolites with a wide range of important biological activities com...
确定活性氧(ROS)生成在Ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid (5F)所诱导的HepG2细胞凋亡中的作用。 方法 :采用MTT分析检测5F对HepG2细胞增殖的影响,再以 Hoechst/PI法分析凋亡细胞的形态变化。为了评价细胞内ROS水平,采用了GENMED试剂盒。HepG2细胞经5F处理24 h,或1 mmol·L-1 GSH预处理1 ...
ENT Problems of Diving
DIVING EAR barotrauma sinus OTOLARYNGOLOGY Otitis externa infection
2009/5/26
The common causes of nasal obstruction are septal deviation, allergy, polyps,
vasometer rhinitis and infection. Polyps are usually the result of allergy or
infection.
Acute sinusitis, often precipi...
Intelligent Bayes Classifier (IBC) for ENT infection classification in hospital environment
Intelligent Bayes Classifier (IBC) ENT infection classification hospital environment
2010/2/26
Electronic Nose based ENT bacteria identification in hospital environment is a classical and challenging problem of classification. In this paper an electronic nose (e-nose), comprising a hybrid array...
ONE-DIMENSIONAL STEADY FLOW-SEDIM ENT MATHEMATIC MODELS HELIUS AND THEIR APPLICATION IN THE THREE GORGES PROJECT
ONE-DIMENSIONAL STEADY FLOW-SEDIM ENT MATHEMATIC MODELS HELIUS THEIR APPLICATION THREE GORGES PROJECT
2013/7/19
In order to investigate the sediment problem of the Three Gorges Project (TGP), two 1-D steady flow-sediment mathematic models (i.e., HELIU- 1 and HELIU-2) are de veloped gradually by Changjiang Rive...