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IDENTIFICATION OF NOVEL SMALL MOLECULE INHIBITORS OF PROTEINS REQUIRED FOR GENOMIC MAINTENANCE AND STABILITY
RPA cancer DNA repair
2015/5/25
Targeting uncontrolled cell proliferation and resistance to DNA damaging chemotherapeutics using small molecule inhibitors of proteins involved in these pathways has significant potential in cancer tr...
BME Researchers Identify Proteins That May Provide Lung Cancer Drug Targets
BME Researchers Proteins Lung Cancer Drug Targets
2009/12/17
Researchers from the Biomedical Engineering Department and the Boston University School of Medicine have identified a number of proteins which, when activated, allow researchers to distinguish between...
Phospho-Nbs1 and Mre11 proteins which recognize DSBs co-localize with γH2AX in the nucleus after heat treatment
hyperthermia γH2AX phospho-Nbs1 Mre11 double strand break
2009/7/15
Background: Critical hyperthermia targets in cancer cells have to be clearly identified.
Method: To determine if the DNA double strand break (DSB)-recognizing proteins, phospho-Nbs1 and Mre11, co-loc...
Extracellular heat shock proteins (eHSPs) pilot exogenous antigen into cross-presentation pathway:A superguide from extracellular world to intracellular tour
Heat shock protein Hsp90 Cross-presentation Antigen presenting cell MHC class I molecule
2009/7/15
Heat shock proteins (HSPs) are intracellular chaperone, some of which function as immune adjuvants as well as danger signals for immune system when released into extracellular milieu. These HSPs, alon...
IMMUNOHISTOCHEMICAL EXPRESSION OF p53 AND BCL-2 PROTEINS IN ADVANCED ESOPHAGEAL CANCER PATIENTS
Esophageal cancer p53 Bcl-2 immunohistochemistry molecular markers
2010/2/3
The current challenges in the management of esophageal cancer are to obtain a better understanding of underlying molecular alterations to provide new treatment options. We studied the p53 and Bcl-2 pr...