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Reproductive aging in the Brown Norway rat is characterized by accelerated germ cell apoptosis and is not altered by luteinizing hormone replacement
Brown Norway rat accelerated germ cell apoptosis luteinizing hormone replacement
2009/2/18
Reproductive aging in the male Brown Norway (BN) rat is characterized by decreased Leydig cell steroidogenesis associated with seminiferous tubule dysfunction. This could be a result of a combination ...
Apoptosis pattern elicited by several apoptogenic agents on the seminiferous epithelium of the adult rat testis
Apoptosis pattern apoptogenic agents seminiferous epithelium adult rat testis
2009/2/17
Spontaneous germ cell death during spermatogenesis is an important event, and the usefulness of the seminiferous epithelium as an in vivo model to study apoptosis has been evidenced. Nevertheless, the...
Mild hypothermia induces apoptosis in rat testis at specific stages of the seminiferous epithelium
Cell death spermatogenesis ferti
2009/2/17
This study was designed to determine the effects of short episodes of mild hypothermia on cell apoptosis in the testis of the adult rat. Apoptosis was assessed by in situ DNA 3'-end labeling in the ...
Leydig cell apoptosis in response to ethane dimethanesulphonate after both in vivo and in vitro treatment
Testis cell culture methylprednisolone glucocorticoid
2009/2/17
The biological effects of ethane dimethanesulphonate (EDS) are unique since cytotoxicity in the adult rat is almost exclusively confined to the Leydig cells. For this reason, EDS has been used exten...
Early effects of vasectomy on testicular structure and on germ cell and macrophage apoptosis in the hamster
Male contraception vasectomy germ-cell apoptosis macrophage apoptosis testosterone testis
2009/2/17
This study provides quantitative information on the early (up to 3 months) effects of vasectomy on apoptosis in the hamster testis. Groups of five adult male golden hamsters were either bilaterall...
Heat stress causes testicular germ cell apoptosis in adult mice
Spermatogenesis testis cryptorchidism
2009/2/17
An investigation was undertaken to determine whether the germ-cell loss associated with exposure of the testis to abdominal temperature occurs by apoptosis. Using an adult-mouse model of experimenta...
2-Methoxyacetic acid（MAA）-induced spermatocyte apoptosis in human and rat testes：an in vitro comparison
2-Methoxyethanol human rat seminiferous tubules apoptosis calcium
2009/2/16
2-Methoxyethanol (2-ME) produces adverse reproductive effects in humans at an exposure level that is about 60-fold lower (2.6 mg/m3) than the concentration toxic to rat testes (167 mg/m3), suggest...
Stage-specific apoptosis in the rat seminiferous epithelium：quantification of irradiation effects
Testis rat apoptosis meiosis irradiation
2009/2/16
The effects of 3 Gy local X-irradiation on the adult rat testis were studied together with exact determination of the radiation dose distribution in the testis. Seminiferous tubule segments were i...
Influence of a Leptin Deficiency on Testicular Morphology, Germ Cell Apoptosis, and Expression Levels of Apoptosis-Related Genes in the Mouse
Spermatogenesis seminiferous tubules testis cytomorphometry micro array
2008/12/24
Leptin-deficient (ob/ob) male mice are morbidly obese and exhibit impaired reproductive function. The objective of this study was to assess the effect of a leptin deficiency on testicular morphology...
DNA Damage in Bovine Sperm Does Not Block Fertilization and Early Embryonic Development But Induces Apoptosis After the First Cleavages
Mitotic spindles blastocyst ICSI
2008/12/23
The main goal of this study was to investigate whether and at what level damage of paternal DNA influences fertilization of oocytes and early embryonic development. We hypothesized that posttesticul...
The Relationship Between Human Semen Characteristics and Sperm Apoptosis：A Pilot Study
Semen quality sperm motility sperm morphology DNA diffusion assay
2008/12/23
This work was undertaken to explore the association between human semen characteristics and apoptosis in ejaculated sperm. We collected semen samples from 23 consecutive male patients who presente...
Overexpression of Endothelial Nitric Oxide Synthase in Transgenic Mice Accelerates Testicular Germ Cell Apoptosis Induced by Experimental Cryptorchidism
Immunoblotting TUNEL spermatocytes spermatids spermatogonia
2008/12/23
Surgical induction of cryptorchidism in experimental animals causes testicular germ cell apoptosis and infertility. The mechanisms of germ cell apoptosis have been associated with oxidative stress o...
Apoptosis and Kinematics of Ejaculated Spermatozoa in Patients With Varicocele
Computer-assisted semen analysis terminal deoxynucleotidyl transferase–mediated deoxyuridine-5'-triphosphate nick end labeling Hoechst 33258
2008/12/22
Increased DNA fragmentation is found in sperm from infertile men. Varicocele is an important cause of male infertility, even though it is present in 15% of men who father children. Semen analysis ...
Heat-Induced Apoptosis of Mouse Meiotic Cells Is Suppressed by Ectopic Expression of Testis-Specific Calpastatin
ldhc gene tCAST cell death calpain spermatocytes
2008/12/22
Calpastatin is a naturally occurring inhibitor of calpain, a protease involved in apoptotic cell death. A testis-specific isoform of calpastatin (tCAST) has been identified that is transcribed in ...
Balance of Apoptosis and Proliferation of Germ Cells Related to Spermatogenesis in Aged Men
Apoptosis proliferation Bcl-xl aging spermatogenesis
2008/12/19
To clarify whether germ cell apoptosis is related to a decrease of germ cells in the aged testis with impaired spermatogenesis, we investigated the apoptotic rate of each germ cell type. Testicular ...