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Effects of Pranlukast Hydrate on Airway Hyperresponsiveness in Non-Asthmatic Patients with Japanese Cedar Pollinosis
airway responsiveness allergic rhinitis leukotriene one airway-one disease pranlukast hydrate
2010/11/16
Background: Recent studies have suggested that allergic rhinitis is closely related to bronchial asthma, reflecting the "one airway-one disease" hypothesis. It is unclear if the effects of pranlukast,...
Effect of a leukotriene receptor antagonist, pranlukast hydrate, on airway inflammation and airway hyperresponsiveness in patients with moderate to severe asthma
airway hyperresponsiveness airway inflammation asthma eosinophils leukotriene leukotriene receptor antagonist
2010/11/25
Asthma is characterized by chronic airway inflammation and the recruitment of inflammatory cells, typically eosinophils and lymphocytes, into the airway. Although several chemical mediators are releas...
Population pharmacokinetics of pranlukast hydrate dry syrup in children with bronchial asthma
children with bronchial asthma population pharmacokinetics pranlukast
2010/11/24
Apparent clearance (CL/F) was 1.81 and 1.14 L/h per kg in children and adults, respectively. According to subgrouping of children, no significant difference was observed in CL/F between infants (3-6 y...