搜索结果: 1-15 共查到“细胞生物学 protein”相关记录16条 . 查询时间(0.184 秒)
在肿瘤获得血液供应的几种方式中，肿瘤细胞转分化为血管细胞是受到密切关注的研究领域之一。多形性胶质母细胞瘤（Glioblastoma multiforme，GBM）是最为多发的成人颅内恶性肿瘤，具有侵袭性强、异质性高、血供丰富、易复发等特征。即使结合放、化疗，病人的中位存活时间也不超过15个月。GBM中包含多种恶性肿瘤细胞和正常基质细胞，其中血管的细胞组分主要包括内皮细胞和包绕内皮、具有平滑肌特征的...
2022年6月28日，在科睿唯安发布的2021年度《SCI期刊引证报告》（Journal Citation Reports）中，中国生物物理学会参与主办的期刊《Protein & Cell》2021年度影响因子为15.328，相较上一年度14.87有所提高，在SCI收录的全球细胞生物学学科203种期刊中排名第45位。另外，由Scopus发布的我刊2021年CiteScore指数为19.4，在相关多...
肝母细胞瘤是一种儿童肝脏恶性肿瘤。与肝癌、胆管癌等成人肝脏恶性肿瘤不同，肝母细胞瘤由肝前体细胞发展而来，其成因与乙型肝炎病毒感染和肝硬化无关。因缺乏人肝母细胞瘤发生模型，其发病机制研究尚不清晰，药物策略尚不明确。在肝母细胞瘤患者中，80%以上患者肿瘤样本显示Wnt-β-catenin和Hippo-YAP通路的过度激活【1】。研究表明，成年小鼠肝脏中共同表达激活型β-catenin和YAP1能够导致...
衰老与一系列组织功能障碍引起的疾病发病率增加密切相关【1,2】。在自然衰老过程中机体内出现的促炎症反应状态慢性进行性升高的现象，被称为 “炎性衰老” ，是导致年龄相关的免疫失衡的常见原因【3】。自然衰老过程中免疫学变化通常表现为多种免疫细胞组成的改变和免疫功能下降。最近的研究表明，相比于年轻群体，老年群体中新型冠状肺炎（COVID-19）的发病率、危重症发生率以及死亡率显著增加【4,5】。然而目前...
2018年3月30日，清华大学免疫学研究所曾文文课题组在《Protein & Cell》杂志在线发表题为“Whole-tissue 3D imaging reveals intra-adipose sympathetic plasticity regulated by NGF-TrkA signal in cold-induced beiging”的研究论文，揭示脂肪组织中交感神经的可塑性特征及动...
Multiple vital cellular processes are regulated by specific interactions between proteins and examples of pathways mediated by protein-protein interactions (PPIs) include gene expression, proliferatio...
Protein Evolution in Different Cellular Environments: Cytochrome b in Sharks and Mammals’
Cellular Environment Sharks and Mammals’
2015/12/17
DNA sequences for the mitochondrial cytochrome b gene were determined for 13
species of sharks. Rates and patterns of amino acid replacement are compared for
sharks and mammals. Absolute rates of ...
Protein evolution in two co-occurring types of Symbiodinium: an exploration into the genetic basis of thermal tolerance in Symbiodinium clade D
Symbiodinium Thermal tolerance Coral
2015/12/11
The symbiosis between reef-building corals and photosynthetic dinoflagellates (Symbiodinium) is an
integral part of the coral reef ecosystem, as corals are dependent on Symbiodinium for the majority ...
Cellular strategies of protein quality control
Cellular strategies protein quality control
2015/12/11
Eukaryotic cells must contend with a continuous stream of misfolded proteins that compromise the cellular protein homeostasis balance and jeopardize cell viability. An elaborate network of molecular c...
Humoral and cellular immune response to Histophilus somni recombinant heat shock protein 60 kDa in farm animals
rHsp60 Histophilus somni subunit vaccine calves piglets hens
2015/11/26
The aim of this study was to evaluate the effects of immunising farm animals with the Histophilus somni recombinant heat shock protein 60kDa (H. somni rHsp60) in field conditions. Fifty piglets, 10 ca...
Protein Classification By Analysis of confocal Microscopic Images of Single Cells
image analysis feature selection classification
2015/7/14
Proteins being present in a living cell fulfil a certain task in the cell. As a consequence of its functionality a protein is located in
certain parts of the cell. If it is made visible the resulting...
Regulating Lipid Organization and Investigating Membrane Protein Properties in Physisorbed Polymer-tethered Membranes
Lipopolymer buckling lipid rafts
2015/5/21
Cell membranes have remarkable properties both at the microscopic level and the molecular level. The current research describes the use of physisorbed polymer-grafted lipids in model membranes to inve...
Cyclooxygenase and cyclic AMP -dependent protein kinase regulate actin organization and cell motility
Cells extracellular matrix cell signal cytoskeleton the cancer cells
2014/12/11
Cell adhesion to an extracellular matrix plays a critical role in many aspects of normal cell function. Cells display various modes of interaction with the extracellular matrix; they may attach and sp...
Formation and plasticity of glutamatergic synapses: Characterization of the roles of beta-amyloid precursor protein, scribble, and wingless at the Drosophila neuromuscular junction
Neurons circuit static core
2014/12/11
The flow of information through neuronal circuits relies on the ability of neurons to form synaptic connections with specific temporal and spatial properties. These properties are not static but have ...
New technique allows study of protein folding, dynamics in living cells
New technique protein folding living cells
2010/3/4
A new technique to study protein dynamics in living cells has been created by a team of University of Illinois scientists, and evidence yielded from the new method indicates that an in vivo environmen...