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中国科学院动物研究所专利：Fusion protein for inducing pluripotent stem cells and application method thereof
中国科学院动物研究所 专利 哺乳动物 YAP蛋白 转录控制活性
2024/5/31
提供了由哺乳动物YAP蛋白或具有转录控制活性的片段的融合蛋白的与细胞全能性和转录激活结构域相关的基因编码的蛋白、编码核苷酸序列、表达载体及其组合物，以及使用该融合蛋白诱导多能干细胞的方法。
中国科学院动物研究所专利：Delayed senescence, malignant conversion of human mesenchymal stem cells can be a resistor, its preparation and use
中国科学院动物研究所 专利 人骨髓间 充质干细胞
2024/5/30
延缓衰老，制备恶性人骨髓间充质干细胞的方法可抗选择性。 制备方法， 第二密码子的253个氨基酸残基的FOXO3蛋白， 丝氨酸密码子编码丙氨酸突变的密码子，FOXO3蛋白密码子的第315位氨基酸残基，丝氨酸密码子编码丙氨酸突变的密码子编码2个突变中的一个突变，编码多能干细胞的基因组包括该步骤。 制备的重组间充质干细胞，并进一步提供其在移植治疗中的用途。 [附图]
Engineers devise a way to selectively turn on RNA therapies in human cells（图）
人类细胞 RNA疗法 治疗性蛋白质 癌症治疗
2023/6/21
Researchers at MIT and Harvard University have designed a way to selectively turn on gene therapies in target cells, including human cells. Their technology can detect specific messenger RNA sequences...
Different cell types—say, heart, liver, blood, and sperm cells—possess characteristics that help them carry out their unique jobs in the body. In general, those characteristics are hard-wired. Without...
A typical bacterial genome contains more than 4,000 genes, which encode all of the proteins that the cells need to survive. How do cells know just how much of each protein they need for their everyday...
New CRISPR-based tool inserts large DNA sequences at desired sites in cells（图）
CRISPR 新型工具 大DNA序列 PAST 基因工程
2023/6/21
Building on the CRISPR gene-editing system, MIT researchers have designed a new tool that can snip out faulty genes and replace them with new ones, in a safer and more efficient way.
分子遗传学前沿讲座：RNA structure, a hidden regulator in living cells（时间：2022年7月27日14:00）（图）
分子遗传学 前沿讲座 RNA结构 丁一倞
2023/4/9
分子遗传学前沿讲座：RNA structure, a hidden regulator in living cells（时间：2022年7月27日14:00）。
Within a given tissue or organ, cells may appear very similar or even identical. But at the molecular level, these cells can have small differences that lead to wide variations in their functions.
Cells in complex organisms undergo frequent changes, and researchers have struggled to monitor these changes and create a comprehensive profile for living cells and tissues. Historically researchers h...
MIT researchers have discovered that before cells start to divide, they do a little cleanup, tossing out molecules that they appear not to need anymore.
Acommon building material, asbestos is the term used to describe a range of naturally growing minerals. Serious diseases, including mesothelioma and lung cancer, can arise decades after coming into co...
Cells人嗅觉粘膜细胞模型
嗅觉粘膜；细胞模型
2022/2/17
在库奥皮奥大学医院的临床医生的合作下，研究人员收集了几年来认知健康的个体和诊断为阿尔茨海默病的患者的鼻活检。在组织处理之后，研究人员应用了一种强大的单细胞RNA测序方法来描述患者来源的嗅粘膜细胞，位于鼻腔的上半部分。嗅觉粘膜组织通过其投射到大脑的嗅觉受体神经元对嗅觉的感知至关重要。
While neurons and glial cells are by far the most numerous cells in the brain, many other types of cells play important roles. Among those are cerebrovascular cells, which form the blood vessels that ...
Despite its minute size, a single cell contains billions of molecules that bustle around and bind to one another, carrying out vital functions. The human genome encodes about 20,000 proteins, most of ...
Cornell researchers have for the first time successfully imaged the entire depth of the lymph nodes in a living mouse using three-photon microscopy. The breakthrough technique’s micrometer clarity and...