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Transcobalamin 776C→G polymorphism is associated with peripheral neuropathy in elderly individuals with high folate intake
folate folic acid peripheral neuropathy TCN2 776C>G polymorphism transcobalamin vitamin B-12
2018/12/19
Background: The 776C→G polymorphism of the vitamin B-12 transport protein transcobalamin gene (TCN2) (rs1801198; Pro259Arg) is associated with a lower holotranscobalamin concentration in plasma. This ...
Applying inappropriate cutoffs leads to misinterpretation of folate status in the US population
deficiency insufficiency microbiologic assay'NHANES'radioprotein-binding assay
2018/12/19
Background: Folate cutoffs for risk of deficiency compared with possible deficiency were originally derived differently (experimental compared with epidemiologic data), and their interpretations are d...
Dietary folate, B vitamins, genetic susceptibility and progression to advanced nonexudative age-related macular degeneration with geographic atrophy: a prospective cohort study
folate B vitamins geographic atrophy macular degeneration genetics
2018/11/29
Background: There is growing evidence of the importance of nutrition in age-related macular degeneration (AMD), but few studies have explored associations with folate and B vitamins. No effective ther...
Vitamin B-12 treatment of asymptomatic, deficient, elderly Chileans improves conductivity in myelinated peripheral nerves, but high serum folate impairs vitamin B-12 status response assessed by the combined indicator of vitamin B-12 status
folate vitamin B-12 holotranscobalamin methylmalonic acid total homocysteine folic acid fortification nerve conductivity elderly Chile
2018/11/26
Background: It is uncertain whether vitamin B-12 supplementation can improve neurophysiologic function in asymptomatic elderly with low vitamin B-12 status or whether folate status affects responses t...
Induction of Folate Sensitive Chromosomal Fragile Sites by Fudr in Pakistani Lohi Sheep (Ovis aries)
Folate Sensitive Chromosomal Fragile Fudr Pakistani Lohi Sheep
2016/4/28
An investigation to determine frequency and distribution of folate sensitive chromosomal fragile sites was carried out in a Pakistani breed of Lohi sheep to uncover fragile site phenomena. The means a...
还原叶酸载体基因（RFC1）与神经管和颅面畸形病因学关系的研究进展 Advances in the Study of the Etiologic Relationship between Reduced Folate Carrier Gene(RFC1) and Neural Tube and Craniofacial Defects
还原叶酸载体基因 神经管和颅面畸形 叶酸 基因多态性
2008/1/10
摘要神经管畸形和颅面畸形是最常见的出生缺陷，由遗传和环境因素共同作用所致，大规模的人群流行病学研究已证实，叶酸能降低发生这类畸形的危险。叶酸缺乏是神经管和颅面畸形发生的主要环境因素，但其机制尚不清楚，通过对与叶酸代谢有关的还原叶酸载体（reduced folate carrier,RFC）的生化特点、生理功能、还原叶酸载体基因（RFC1）结构功能、调控、表达及其与叶酸水平和神经管颅面畸形的关系等研...