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瘦素在SLE中作用的研究进展
瘦素 系统性红斑狼疮 免疫细胞
2020/6/19
瘦素作为脂肪因子家族一员，最初被认为具有调节摄食和产能间能量平衡的作用。随着研究深入，人们发现瘦素除与代谢有关外，还具有影响炎症反应，促进免疫细胞活化、细胞因子分泌及调控免疫应答等功能。已经有研究证实瘦素异常表达与肿瘤、自身免疫病、心血管疾病等具有相关性。SLE是一种严重累及全身多个脏器的自身免疫性结缔组织病，T、B淋巴细胞免疫功能异常，大量自身反应性淋巴细胞浸润及免疫复合物沉积等致靶器官损伤为目...
诱导TLR耐受对SLE的治疗潜能
系统性红斑狼疮 Toll样受体 免疫耐受
2020/6/19
SLE是一种累及全身各系统和器官的慢性自身免疫性疾病，主要特征为体内淋巴细胞异常活化及大量自身抗体异常累积，致使大量异常自身免疫复合物沉积，最终导致多系统器官受损。临床上仍以糖皮质激素联合环磷酰胺等非特异性免疫抑制剂治疗为主，但长期用药导致的毒副作用使SLE患者的平均寿命明显低于健康人。因此，急需探索安全可靠的治疗方法。
给定上半平面内的一个固定点, 获得通弦~$SLE_{\kappa}(0\leqslant \kappa<8)$~迹穿过它右边的概率估计公式. 基于左边界概率的结果, 建立了闭单位圆内临界渗流不包含其内一个固定点的概率估计公式. 最后, 利用探索过程与~$SLE_{6}$~的关系, 得到了起点和终点相同的~$SLE_{6}$~迹与自避型路径有同样的分布.
Following [3], we consider the boundary WZW model on a half–plane with a cut growing according to the Schramm–Loewner stochastic evolution and the boundary fields inserted
at the tip of the cut and a...
Conformal weldings of random surfaces: SLE and the quantum gravity zipper
Conformal weldings of random surfaces: quantum gravity zipper
2011/2/24
We construct a conformal welding of two Liouville quantum gravity random surfaces and show that the interface between them is a random fractal curve called the Schramm-Loewner evolution (SLE), thereby...
Multi-point Green's functions for SLE and an estimate of Beffara
Multi-point Green's functions for SLE estimate of Beffara
2010/11/22
In this paper we define and prove of the existence of the multi-point Green's function for SLE--a normalized limit of the probability that an SLE_\kappa curve passes near to a pair of marked points i...
Discrete holomorphic parafermions in the Ashkin-Teller model and SLE
Discrete holomorphic parafermions Ashkin-Teller model SLE
2010/12/15
We find discrete holomorphic parafermions of the Ashkin-Teller model on the critical line, by mapping appropriate interfaces of the model to the O(n = 1) model. We give support to the conjecture that ...
载体辅助液液萃取(SLE)-GC/MS法快速测定酒饮料中氨基甲酸乙酯
supported
2010/3/30
A method for simple and rapid determination of ethyl carbamate in alcoholic beverages was developed by GC/MS coupling with modified supported liquid-liquid extraction. Dehydrated with sodium chloride-...
SLE血清中抗-DNA抗体分离和性质的研究
系统性红斑狼疮 抗-DNA抗体 血清 亲合层析
2007/12/19
摘要 本文用国产高分子树脂(T)接枝小牛胸腺DNA,通过亲合层析从系统性红斑狼疮SLE患者血清中纯化出抗-ds DNA抗体和抗-ss DNA抗体。酶联免疫吸附分析(ELISA)的研究表明:SLE抗-DNA抗体和DNA结合的差异性很大,是高度非均一性的。抗-ss DNA抗体不仅组成成分比抗-ds DNA抗体复杂,ss DNA/抗-ssDNA亲合能力也明显高于ds DNA/抗-ds DNA。纯化的抗-...
正常人和SLE患者血清中抗DNA抗体的研究
系统性红斑狼疮(SLE) 正常人抗DNA抗体 患者抗DNA抗体 胰蛋白酶解
2007/12/18
摘要 用亲和层析法对6例正常人和4例SLE患者血清中抗DNA抗体进行提取和定量研究,发现正常人血清中抗DNA抗体的组成IgM/IgG大于1,是以IgM为主的抗体,SLE患者血清中抗DNA抗体含量高,IgM/IgG小于1,是以IgG为主的抗体。用胰蛋白酶降解提取的抗DNA抗体再借助于SDS—聚丙烯酰胺凝胶电泳对正常人和SLE患者抗DNA抗体的结构进行初步探讨,电泳结果表明正常人和SLE患者纯化抗DN...