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南京农业大学农学院《New Phytologist》发表植物环境适应分子遗传研究课题组“A major gene for chilling tolerance variation in Indica rice codes for a kinase OsCTK1 that phosphorylates multiple substrates under cold”（图）
植物环境 分子遗传
2024/4/29
水稻起源于热带和亚热带，对低温十分敏感，当温度低于15℃时水稻便无法正常生长。有统计显示，每年低温冷害导致我国水稻减产约50亿kg。近年来，因直播稻大面积推广以及水稻种植区域不断由热带、亚热带向高海拔、高纬度地区扩张，水稻遭受低温冷害的频率有增加趋势。低温冷害已成为限制我国水稻生产的一大瓶颈。因此，挖掘调控水稻耐冷性的关键基因，研究其作用机理，对防控水稻低温冷害具有重要意义。
Enhanced tolerance to low-K+ stress in tobacco plants, that ectopically express the CBL-interacting protein kinase CIPK23 gene
low-K+ tolerance potassium tobacco
2016/7/6
Tobacco (Nicotiana tabacum) has a relatively high requirement for potassium (K+). However, the molecular basis of tolerance to low-K+ stresses in tobacco still remains unknown. Here, we report the rol...
A conserved water-mediated hydrogen bond network defines bosutinib’s kinase selectivity
Humans Water Quinolines Nitriles Aniline Compounds src-Family Kinases Amino Acid Substitution Conserved Sequence Substrate Specificity Hydrogen Bonding
2016/5/25
Kinase inhibitors are important cancer drugs, but they tend to display limited target specificity, and their target profiles are often challenging to rationalize in terms of molecular mechanism. Here ...
Structural and Spectroscopic Analysis of the Kinase Inhibitor Bosutinib and an Isomer of Bosutinib Binding to the Abl Tyrosine Kinase Domain
Humans Escherichia coli Benzamides Quinolines Nitriles Aniline Compounds Piperazines Pyrimidines Thiazoles Recombinant Proteins
2016/5/25
Chronic myeloid leukemia (CML) is caused by the kinase activity of the BCR-Abl fusion protein. The Abl inhibitors imatinib, nilotinib and dasatinib are currently used to treat CML, but resistance to t...
The Effects of Glucagon-like Peptide-2 on the Tight Junction and Barrier Function in IPEC-J2 Cells through Phosphatidylinositol 3-kinase–Protein Kinase B–Mammalian Target of Rapamycin Signaling Pathway
Transepithelial Electrical Resistance Phosphatidylinositol 3-Kinase-Akt-mTOR Signaling Pathway
2016/5/20
Glucagon-like peptide-2 (GLP-2) is important for intestinal barrier function and regulation of tight junction (TJ) proteins, but the intracellular mechanisms of action remain undefined. The purpose of...
Inhibition of c-Jun N-terminal kinase (JNK) suppresses porcine oocyte ageing in vitro
MAPK DNA fragmentation apoptosis Bax
2015/6/24
Oocyte ageing is a complex of processes that occur when matured in vitro oocytes are, after reaching the metaphase II stage, exposed to further in vitro culture. Aged oocytes remaining at the metaphas...
Effects of protein kinase C on parthenogenetic activation of pig oocytes using calcium ionophore or nitric oxide-donor
oocyte pig parthenogenesis activation calcium ionophore nitric oxide
2015/6/4
Porcine oocytes matured in vitro were activated for parthenogenetic development using either calcium ionophore (50μM for 10 min) or nitric oxide donor SNAP (2mM for 23.5 hours). Protein kinase C (PKC)...
Characterization of the Mitochondrial Proteome in Pyruvate Dehydrogenase Kinase 4 Wild-Type and Knockout Mice
Starvation Mitochondria Proteomics PDK4
2015/5/25
The goal of this study was to determine the effect of a PDK4 (pyruvate dehydrogenase kinase isoenzyme 4) knock-out on mitochondrial protein expression. A 2-D gel based mass spectrometry approach was u...
The role of pyruvate dehydrogenase kinase in glucose and ketone body metabolism
ketoacidosis hypothermia fatty acid pyruvate carboxylase
2015/5/25
The expression of pyruvate dehydrogenase kinase (PDK) 2 and 4 are increased in the fasted state to inactivate the pyruvate dehydrogenase complex (PDC) by phosphorylation to conserve substrates for glu...
The influence of the Ku80 carboxy-terminus on activation of the DNA-dependent protein kinase and DNA repair is dependent on the structure of DNA cofactors
DNA-PK Ku70/80 Ku80 Carboxy Terminus
2015/5/25
In mammalian cells DNA double strand breaks (DSBs) are highly variable with respect to sequence and structure all of which are recognized by the DNA- dependent protein kinase (DNA-PK), a critical comp...
Molecular Characterization and Expression Analysis of Creatine Kinase Muscle (CK-M) Gene in Horse
Horse Biomarker Creatine Kinase Muscle Exercise Quantitative-polymerase Chain Reaction
2016/5/19
Since ancient days, domestic horses have been closely associated with human civilization. Today, horse racing is an important industry. Various genes involved in energy production and muscle contracti...
The role of cell cycle progression and cyclin -dependent kinase 2 in thymocyte negative selection
T cells and thymus cells thymus self antigen cells
2014/12/11
Autoreactive, immature T cells (thymocytes) are deleted from the thymus during development by the process of negative selection. This mechanism occurs when the thymocyte, T cell receptor (TCR) recogni...
Cyclooxygenase and cyclic AMP -dependent protein kinase regulate actin organization and cell motility
Cells extracellular matrix cell signal cytoskeleton the cancer cells
2014/12/11
Cell adhesion to an extracellular matrix plays a critical role in many aspects of normal cell function. Cells display various modes of interaction with the extracellular matrix; they may attach and sp...
Receptor clusters and dynamics in kinase regulation in bacterial chemotaxis
Signal transduction bacterial chemotaxis systems membrane membrane protein cytoplasmic form complex signaling proteins
2014/12/11
Signal transduction in bacterial chemotaxis system is mediated by a family of transmembrane proteins that are clustered in the membrane and form noncovalent complexes with cytoplasmic signaling protei...
Feronia: A Malectin-Like Domain-Containing Receptor Kinase in Arabidopsis Thalina
Pure sciences Biological sciences Malectin-like Domain-containing Receptor kinases Arabidopsis thaliana Polarized cell growth Pollen tube - Pistil interactions Sugar signaling
2014/12/10
RAC/ROPs are a unique group of RAS-related monomeric G proteins (small G proteins) that constitute the sole family of Rho GTPases in plants. RAC/ROPs, like their counterpart Rho GTPases from mammalian...