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代谢重编程是肿瘤的基本特征之一。肿瘤细胞即使在氧气充足的条件下仍优先通过糖酵解途径而不是线粒体氧化磷酸化产生能量，这种现象被称为Warburg效应。这种异常的代谢方式导致肿瘤细胞过度依赖葡萄糖代谢产生乳酸，并同时抑制了三羧酸（TCA）循环等氧化代谢途径，减少了细胞内氧化压力并同时产生大量用于生物合成的代谢中间体，促进肿瘤细胞的快速增殖。肿瘤细胞如何协调糖酵解以及TCA循环也一直是肿瘤代谢领域的重点...
2022年1月21日，中国科学院上海营养与健康研究所章海兵研究组在国际学术期刊Cell Death and Differentiation在线发表了题为“Caspase-8 auto-cleavage regulates programmed cell death and collaborates with RIPK3/MLKL to prevent lymphopenia”的研究成果。该研究揭示...
浙江大学生命科学研究院张龙实验室在Cell Death & Differentiation发表论文阐述SUMO介导的核受体泛素化调控巨噬细胞凋亡（图）
浙江大学生命科学研究院 张龙实验室 Cell Death & Differentiation SUMO介导 核受体泛素化 巨噬细胞凋亡
2017/7/6
2017年6月16日，张龙实验室在Cell Death & Differentiation发表题为“SUMO-triggered ubiquitination of NR4A1 controls macrophage cell death”的研究论文，揭示SUMO介导的核受体泛素化调控巨噬细胞凋亡。孤核受体NR4A1（nuclear receptor subfamily4,group A,memb...
2017再生生物学和应用 Keystone Symposia （2017 Keystone Symposia on Regenerative Biology and Applications:Cell Differentiation,Tissue Organization and Biomedical Engineering ）
2017 再生生物学和应用 Keystone Symposia
2017/3/10
The four-day Keystone Symposia conference entitled Regenerative Biology and Applications: Cell Differentiation, Tissue Organization and Biomedical Engineering focuses on three important aspects of the...
Characterization of the Methylation Status of Pax7 and Myogenic Regulator Factors in Cell Myogenic Differentiation
Pax7 Myogenic Regulatory Factors C2C12 DNA Methylation CpG Islands
2016/7/27
Epigenetic processes in the development of skeletal muscle have been appreciated for over a decade. DNA methylation is a major epigenetic modification important for regulating gene expression and supp...
Heat Shock Protein Augmentation of Angelica gigas Nakai Root Hot Water Extract on Adipogenic Differentiation in Murine 3T3-L1 Preadipocytes
Angelica gigas Nakai Heat Shock Heat Shock Protein 3T3-L1 Adipogenesis
2016/5/19
There is a high association of heat shock on the alteration of energy and lipid metabolism. The alterations associated with thermal stress are composed of gene expression changes and adaptation throug...
Role of Growth Differentiation Factor 9 and Bone Morphogenetic Protein 15 in Ovarian Function and Their Importance in Mammalian Female Fertility — A Review
Cumulus Cells Granulosa Cells Oocyte Maturation Follicular Development Reproductive Efficiency TGF-β Superfamily
2016/11/10
Growth factors play an important role during early ovarian development and folliculogenesis, since they regulate the migration of germ cells to the gonadal ridge. They also act on follicle recruitment...
Computing Periodic Orbits and their Bifurcations with Automatic Differentiation
Automatic Differentiation Computing Periodic Orbits
2015/8/25
This paper examines algorithms for computing periodic orbits of dynamical systems. Our
goal is to explore the limits of accuracy that are attainable for these calculations within
the pragmatic conte...
The Emergence of Symbiotic Groups Resulting From Skill-Differentiation and Tags
emergence symbiosis groups tags artificial life complementarity predetor-prey dynamics simulation
2015/7/30
The paper presents a evolutionary simulation where the presence of ‘tags’ and an inbuilt specialisa-tion in terms of skills result in the development of ‘symbiotic’ sharing within groups of individual...
Complex Systems Analysis of Arrested Neural Cell Differentiation during Development and Analogous Cell Cycling Models in Carcinogenesis
Cell cycling control of cell division and the neoplastic transformation in carcinogenesis essential roles of high c-Myc p27 Inhibition p53 inactivation and hTERT activation of Telomerase biosynthesis in Malignant Cell Transformation Rational Clinical trials Individualized Medicine and potential for optimized Radio-Chemo- Gene- and Immuno- therapies of Cancers Ł ukasiewicz models of Genetic Networks Genome and cell interactomics models in terms of categories of Ł ukasiewicz logic Algebras and Lukasiewicz Topos Ł ukasiewicz Topos with an n-valued Ł ukasiewicz Algebraic Logic subobject classifier genetic network transformations in Carcinogenesis developmental processes and Evolution/ Evolutionary Biology Relational Biology of Archea yeast and higher eukaryotic organisms nonlinear dynamics in non-random hierarchic genetic networks proteomics coupled genomes via signaling pathways mechanisms of neoplastic transformations of cells and topological grupoid models of genetic networks in cancer cells natural transformations of organismic structures in Molecular Biology
2015/7/30
A new approach to the modular, complex systems analysis of nonlinear dynamics of arrested neural cell Differentiation--induced cell proliferation during organismic development and the analogous cell c...
The Selection and Validation of a Marker Set for the Differentiation of Onion Cultivars from the Czech Republic
genotyping SSR markers variety testing
2015/7/2
The onion (Allium cepa L.) constitutes an important part of the human diet and is of economic importance
on the vegetable market. Methods that allow unambiguous differentiation of cultivars and bree...
The Selection and Validation of a Marker Set for the Differentiation of Onion Cultivars from the Czech Republic
genotyping SSR markers variety testing
2015/7/2
The onion (Allium cepa L.) constitutes an important part of the human diet and is of economic importance
on the vegetable market. Methods that allow unambiguous differentiation of cultivars and bree...
Identification of a Minimal Cis-element and Cognate Trans-factors Required for the Regulation of Rac2 Gene Expression during K562 Cell Differentiation
Rac2 Gene Expression
2015/5/25
This dissertation examines the molecular mechanisms regulating Rac2 gene expression during cell differentiation and identification of a minimal cis-element required for the induction of Rac2 gene expr...
Characterization of Bovine NANOG5′-flanking Region during Differentiation of Mouse Embryonic Stem Cells
Bovine Embryonic Stem Cell NANOG Promoter Neural Differentiation Adipocyte Differentiation
2016/5/19
Embryonic stem cells (ESCs) have been used as a powerful tool for research including gene manipulated animal models and the study of developmental gene regulation. Among the critical regulatory factor...
Possibilities of differentiation of individual Achillea species on the basis of redox potential measurements
yarrow Achillea Achillea species redox potentia
2015/1/20
he redox potential of flowers of Achillea plants was measured by means of a puncture method. Measurements were performed in 6 taxa (species and hybrids) in the stage of bud formation, full flower and ...